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Something rotten is brewing beneath the industrial mecca known as Raccoon City. Unknown to its millions of residents a huge underground bioengineering facility known as The Hive has accidentally unleashed the deadly and mutating T-virus killing all of its employees. To contain the leak the governing supercomputer Red Queen has sealed all entrances and exits. Now a team of highly-trained super commandos including Rain (Michelle Rodriguez), Alice (Milla Jovovich), and Matt (Eric Mabius) must race to penetrate The Hive in order to isolate the T-virus before it overwhelms humanity. To do so they must get past the Red Queen's deadly defenses face the flesh-eating undead employees fight killer mutant dogs and battle The Licker a genetically mutated savage beast whose strength increases with each of its slain victims.